Highlights

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• Undetected coronary artery disease (CAD) carries significant morbidity and mortality while remaining the leading cause of death. 

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• A novel biomarker-based model to predict presence of CAD has potential to non-invasively diagnose CAD and has been shown to increase the accuracy of predicting clinically significant CAD in a prior exploratory study. 

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• Study objective was to externally validate a recently developed proteomic assay’s ability to diagnose obstructive CAD (Prevencio HART CAD) in a prospective cohort of patients undergoing diagnostic catheterization. 

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• Prospective patients referred to cardiac catheterization at single-center were enrolled and blood specimens were obtained pre-angiography. A total of 500 patients were enrolled over a 6-month period.

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• The score had a diagnostic odds ratio of 4.69 (p<0.001; 3.22, 6.84) and AUC 0.74 compared to original validation cohort (n=278) which had diagnostic odds ratio of 9.74 (p<0.001; 6.05, 16.1) and AUC 0.87.

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• Younger cohorts had AUC 0.81 and may demonstrate higher performance. Patients were referred for angiography for various acute and non-acute indications.

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