ACC 2019 External Validation Presentation for HART CVE

Validation of a Novel AI-driven multi-biomarker Panel for Accurate Prediction of Incident Cardiovascular Events in Patients with Suspected Myocardial Infarction.

March 17, 2019

Highlights

  • Predicting future cardiovascular events (CVE) in patients presenting with suspected myocardial infarction (MI) is an unmet clinical need. In a population of patients with suspected MI presenting to the emergency department, we sought to externally validate a multiple biomarker panel for prediction of incident CVE.

 

  • 748 patients presenting with suspected MI to the emergency department were prospectively recruited. A multiplex assay including 4 biomarkers (NT-proBNP, KIM-1, osteopontin, TIMP-1) was measured in blood samples. A predictive score ranging from 0 to 10 had been previously derived in 649 stable and unstable patients with suspected coronary artery disease (CAD) or MI in the CASABLANCA trial.

 

  • All patients were followed for one year to assess incident CVE (composite of CV death and incident MI).

 

  • Application of the prognostic score resulted in an area under receiver operating characteristic curve (AUC) of 0.86 (p<0.001). Application of the optimal cutoff resulted in a high negative predictive value of 99.4% (95%CI 98.7%,100%) and a sensitivity of 86.4% (95%CI 72.0%,100%) for incident CVE. Patients with a prognostic score above the cutoff were more likely to develop a CVE, compared to patients below the cutoff.

 

  • In this external validation study of patients with suspected MI, the Prevencio HART CVE panel provided high accuracy for predicting incident CVE within one year of follow up.

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The ACC 2019 External Validation Presentation for HART CVE

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